Recombinant Holotoxoid Vaccine against Botulism
نویسندگان
چکیده
منابع مشابه
Recombinant holotoxoid vaccine against botulism.
The botulinum neurotoxins (BoNT) are the most toxic proteins for humans and designated "Category A Select Agents." The current vaccine against botulism is in limited supply, and there is a need to develop new vaccine strategies. A recombinant BoNT/A toxoid was produced in Clostridium botulinum that contained a double amino acid substitution, R363A Y365F (termed BoNT/A(RYM)). BoNT/A(RYM) was non...
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Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis. The BoNTs C and D are the main serotypes responsible for botulism in animals, including buffaloes. Botulism is one of the leading causes of death in adult ruminants in Brazil due to the high mortality rates, even though botulism in ...
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Botulinum neurotoxins (BoNTs) are the most toxic proteins for humans and are classified as category A toxins. There are seven serotypes of BoNTs defined by the lack of cross-serotype toxin neutralization. Thus, an effective vaccine must neutralize each BoNT serotype. BoNTs are organized as dichain A-B toxins, where the N-terminal domain (light chain) is a zinc metalloprotease targeting soluble ...
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Modified IAI00843-07 Version2 1 2 A recombinant Holo-toxoid Vaccine against Botulism 3 4 Christina L. Pier, William H. Tepp, Marite Bradshaw, Eric A. Johnson, Joseph 5 T. Barbieri, and Michael R. Baldwin*. 6 7 Food Research Institute, University of Wisconsin, Madison, Wisconsin and 8 Department of Microbiology and Molecular Genetics, Medical College of 9 Wisconsin, Milwaukee, Wisconsin. 10 11 *...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2008
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00843-07